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Resveratrol is the active ingredient in red
wine that helps explain the "French paradox," namely that the French
typically eat a diet quite high in saturated fat, yet suffer a low rate
of atherosclerotic heart disease. Resveratrol appears to work as a
powerful antioxidant helping quench free radical damage in the body1,
but also has a unique mechanism of action that may prove to have
significant life extension properties. Resveratrol appears to help
maintain healthy DNA and plays an important role in protecting cells and
supporting mitochondrial function.2,9
Resveratrol may produce benefits similar to caloric restriction (CR).3,
7 The most powerful means of extending life span in animals appears to
be through CR. While CR has not been shown to result in life extension
in humans, some early studies suggest it may produce this desirable
benefit.4 However, restricting calories by 30 percent or more is
necessary to produce these benefits is very difficult for most people.
Research has focused on compounds that affect SIRT1, the gene that seems
most closely linked with life extension from caloric restriction.
Polyphenols offer benefits besides their ability to scavenge free
radicals and help prevent oxidation. They also support venous health and
healthy circulation.10 The anti-inflammatory, antioxidant, and
antiproliferative effects of resveratrol in the pulmonary arteries may
also help maintain circulatory health.8
One of the difficulties with resveratrol is that it is easily oxidized
and difficult to absorb. Research suggests taking resveratrol with
lecithin can enhance absorption;5,6 therefore, if you take a
lecithin-derived phosphatidylcholine(such as Ray & Terry's PC (Phosphatidylcholine).
We recommend that you take it at
the same time as resveratrol to enhance absorption.
Dosage: As a dietary supplement, take 1 or
2 capsules daily. This is a highly concentrated product and contains 500
mg gross resveratrol per capsule, standardized to yield 250 mg trans-resveratrol
per capsule.
Ray & Terry's Resveratrol
contains 60 vegetarian
capsules per bottle.
Proper Storage: Resveratrol is easily
oxidized. However, proper storage will ensure that it does not oxidize.
We use an opaque bottle to minimize light exposure. We recommend storing
resveratrol in a cool, dry, place in its tightly sealed container.
Ray & Terry's Resveratrol is equally
effective when taken with or without food. However, if your digestive
system is sensitive, you may want to take your supplements with meals.
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About
Red Wine and Absorption Rates
Note from the Longevity
Experts: Our product offers 200mg with 50 mg estimated of actual
absorption because of oxidation. Resveratrol oxidizes very
quickly and leaves the body quickly. Depending
on the oxidation/absorption factor one of our 50 mg. capsules
twice daily which would compare to either two liters of red wine
(8 glasses) or 8 liters (36 glasses) of red wine and it is best
taken with Phosphatidylcholine which is reported to increase
absorption.
Red wine offers as much as 40 mg of Resveratrol per liter, as
suggested by some studies
( http://en.wikipedia.org/wiki/Resveratrol
), and one liter is about equal to 4 glasses.
In an interview with Dr. Sinclair (the author of the study
reported on in the news), he stated that he has been taking a
supplement of Resveratrol and that it is absolutely safe. |
Supplement Facts
| Serving Size: 1
Veggie Capsule |
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| Amount Per Serving |
% Daily Value
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Resveratrol
Extract
(250 milligrams of elemental Trans-Resveratrol from 500mg’s of
polygonum cuspidatum 50% standardized extract.) |
250 mg
|
* |
*% Daily Value Not Established
Percent daily values are based on a 2000 calorie diet
Other Ingredients: Rice flour, vegetable
stearate,
and veggie caps (vegetable cellulose) and lemon grass. Formula includes
NO animal products CAUTION: Do not exceed recommended dose.
Pregnant or nursing mothers, children under 18, and individuals with a
known medical condition should consult a physician before using this or
any dietary supplement.
References:
-
Br J Pharmacol. Oct;131(4):711-720. S. Bastianetto et al.
2000.
-
Mutat Res. Sep 20;496(1-2): 171-180. A. Sgambato et al. 2001.
-
Nature 2003 Sep 11;425(6954):191-6. Howitz KT et al.
-
Microsc Res Tech. Nov 15;59(4):335-338. M. A. Lane et al.
2002.
-
J Agriculture Food Chemistry 6; 50:1706-12, 2002
-
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):2950-8. Hung
CF et al.
- BMC Syst Biol. Mar 10;3:31. JJ
Smith et al. 2009.
- Hypertension. 2009 Jul 13. [Epub
ahead of print] A. Csiszar et al. 2009.
- J Appl Toxicol. 2009 Jul 14. [Epub
ahead of print]. K. Svechnikov et al. 2009
- Exp Clin Cardiol.
Fall;11(3):217-25. R Vidavalur et al. 2006.
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Read This:
-
You should be comparing quality, not prices!
-
But, if you are comparing prices, look at the number of capsules or tablets and
the measured amount of the active ingredients.
-
You may be surprised to find that the lower cost bottle does not contain as much
and is more expensive per dose!
-
Our products are not the highest priced, just the highest quality!
Our products
are Distinctive
and Specially Formulated!
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Red wine may
help impede cancer
United Press International UPI
Feb. 2010
NEW YORK, Feb. 26 (UPI) -- Derivatives of
resveratrol-- found in red
wine grapes -- may impede cancer cell development, U.S.
researchers said.
The National Cancer Institute has teamed with a biotech firm to
examine the potential benefit of
resveratrol among cancer patients.
Dr. Bryan C. Donohue of the University of Pittsburgh Medical
Center, Shadyside Hospital, says early-stage clinical trials now
under way are examining
resveratrol's effectiveness among patients with heart
disease, cancer, dementia and a host of other modern illnesses.
In the meanwhile, some people simply looking for greater energy,
enhanced clarity of thought and advanced overall well being are
already benefiting from
resveratrol supplementation, Donohue said.
CBS
News Reports:
A new study shows an antioxidant found in red wine destroys cancer
cells from the inside and enhances the effectiveness of radiation
and chemotherapy cancer treatments.
Researchers say the antioxidant found in grape skins, known as
resveratrol, appears to work by targeting the cancer cell's energy
source from within and crippling it. When combined with radiation,
treatment with resveratrol prior to radiation also induced cell
death, an important goal of cancer treatment.
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New study of fish shows longer life
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New: Recently, a small fish species
with a captive lifespan of only three months was given Resveratrol
supplements. In the new study, the researchers used this
short-lived fish to test the effects of resveratrol on
aging-related physiological decay. The researchers added
resveratrol to daily fish food and found that this treatment
increased longevity and also retarded the onset of aging-related
decays in memory and muscular performance.
-----------------------
The Washington Post
Is substance in red wine the secret to long life?
WASHINGTON — A substance found in red wine protected mice from the ill effects of obesity, raising the tantalizing prospect that the compound could do the same for humans and may also help people live longer, healthier lives, researchers reported Wednesday.
Red wine to prevent colon
cancer
Red wine
consumption is associated with a reduced risk of various forms of
cancer--leukemia, breast and prostate, in animal studies and in real life.
A new study found that drinking more than three glasses of red wine a week
reduced the incidence of abnormal growths and cancers of the intestinal
tract by two-thirds.
More from the Washington Post
article:
The substance, called resveratrol, enabled mice that were fed a high-calorie, high-fat diet to live active lives despite becoming obese — the first time any compound has been shown to do that. Tests found it activated genes that protect against the effects of aging, essentially neutralizing the harmful effects of a bad diet on the animals' health and life span.
Although much more work is needed to explore the safety and benefits of the substance, which is sold over the counter as a nutritional supplement, the findings could lead to the long-sought goal of extending the healthy human life span, experts said. Preliminary tests in people are under way.
"We've been looking for something like this for the last 100,000 years, and maybe it's right around the corner — a molecule that could be taken in a single pill to delay the diseases of aging and keep you healthier as you grow old," said David Sinclair, a Harvard University molecular biologist who led the study. "The potential impact would be huge."
The findings triggered excitement among scientists who study aging. They hailed the findings as groundbreaking.
"This represents a likely major landmark," said Stephen Helfand, who studies the molecular genetics of aging at Brown University in Providence, R.I. "This really pushes the field forward. It's quite exciting."
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Ray & Terry's Products*
As featured in the book "How to Live Long Enough
to Live Forever"
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